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Writer's pictureRedwood Naturopathic Medicine

Mast Cell Activation Syndrome (MCAS)

What is Mast Cell Activation Syndrome (MCAS)?

Mast Cell Activation Syndrome (MCAS) is a condition where certain immune cells, called mast cells, become overly reactive. These cells are important for defending the body against infections and healing wounds. They also release chemicals, like histamine, during allergic reactions and immune responses. In MCAS, however, mast cells release too many chemicals, especially histamine, too often or inappropriately. This excess histamine can contribute to a variety of symptoms, including headaches, hives, digestive issues, and more. Dr. Amanda Wilms has a great deal



of knowledge and experience working with MCAS, including how to manage histamine-related symptoms. If you think you may have MCAS or want to explore natural options for symptom management, reach out to our office to schedule time with Dr. Amanda Wilms. She can help you develop a customized treatment plan suited to your unique needs.



Common Symptoms of MCAS

MCAS symptoms can vary from person to person, but the most common ones include:

  • Allergic-like reactions: Hives, swelling, itching, or flushing of the skin.

  • Digestive issues: Nausea, diarrhea, abdominal pain, bloating, or vomiting.

  • Breathing difficulties: Wheezing, coughing, or shortness of breath, similar to asthma.

  • Heart and blood pressure changes: Rapid heartbeat, low blood pressure, or dizziness, especially when standing up.

  • Neurological symptoms: Headaches, brain fog, or difficulty concentrating.

  • Fatigue: Persistent tiredness that doesn’t go away with rest.


Because MCAS can affect many different systems in the body, it often gets mistaken for other conditions like allergies, irritable bowel syndrome (IBS), or chronic fatigue syndrome.


What Causes MCAS?

The exact cause of MCAS is still being researched. In some people, it might be triggered by genetics, meaning it runs in families. Other factors such as infections, environmental toxins (molds, chemicals, toxic metals), or stress may also play a role in causing mast cells to behave abnormally.


Certain triggers can set off MCAS symptoms. Common triggers include:

  • Certain Foods

  • Heat or cold

  • Stress

  • Infections- bacterial, viral, or parasitic

  • Fragrances and other chemicals


How is MCAS Diagnosed?

Diagnosing MCAS can be tricky because the symptoms overlap with many other conditions. Doctors usually perform blood tests and urine tests to check for elevated levels of chemicals released by mast cells, especially during or after an episode of symptoms. It’s important to track your symptoms and triggers to help with diagnosis.


Living with MCAS

Living with MCAS can be challenging, but with the right care, many people are able to manage their symptoms and lead fulfilling lives. It is best to begin by working with your specialized healthcare team to find care catered to your individual needs. MCAS often requires a multi-faceted approach, so it’s helpful to work with doctors who understand the condition and can tailor treatment to your specific needs. Our own, Dr. Amanda Wilms, has a great deal of knowledge and experience working with MCAS. If you think you may have MCAS or want to explore natural options for symptom management, reach out to our office to schedule time with Dr. Amanda Wilms. She can help you develop a customized treatment plan suited to your unique needs.



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